by
Nicoled » Tue Mar 05, 2019 2:16 pm
AICMM wrote:
Nicoled,
The response factors for FID are, generally, pretty consistent. There are some general exceptions - methanol, chlorinated, etc.... but a wide range of compounds respond in a very similar manner.
So....., I would be a lot more suspicious of the headspace side of this equation than I would be of the FID side of the equation. Then again, if the headspace parameters are consistent, standards to samples should still work out.....
If you can provide it, more information gets a better response.
Best regards,
AICMM
Hi thank you for your reply!
I am using this method (
https://www.restek.com/chromatogram/view/GC_FS0518)
My response factors across my calibration range are like this for most standards:
std 1 (5ug/mL) RF = 5.89495
std 2 (100ug/mL) RF = 9.44077
std 4 (2000ug/mL) RF = 15.13773.
I had been using a calibration range that had been decided by a different analyst, but the more I think about it, the more likely it seems that the response factors are so different because of the huge range of calibration points. I am narrowing them down now (2-250ug/mL now, with more points). Does this make sense?