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- Posts: 22
- Joined: Fri Dec 07, 2012 11:20 pm
In our pharma lab, we need to select the best sample diluent for some HS-GC methods. We have a lot of residual solvents to control.
Could you please give your feedback about the pros and cons of using DMA or NMP? Specially considering:
- availability and cost of pure HS grades
- possible residual impurities (e.g. DMF in DMA) or stabilizers
- "cleanliness" of baseline (e.g. critical interfering peaks)
- solubilizing power for apolar and polar substances
- boiling point and its impact on HS-GC performance (implications on HS oven temperature)
- impact on the extraction of multiple residual solvents
- any other relevant parameter
We have initially rejected DMSO and DMI due to the common degradation/purity/high cost issues.
Thanks in advance