Dimethylformamide as an analyte

Discussions about GC and other "gas phase" separation techniques.

4 posts Page 1 of 1
Hello,

I am looking for some information/experiences on analyzing for DMF by HS-GC-FID. Searching the forum I found a few posts mentioning that there can be problems. Is it due to the boiling point of DMF, is it a "sticky" compound? Anyone have experience testing for DMF by headspace?

Thanks,
Dave
I had much more luck with methods where the API was dissolved in a solvent such as DMSO and a liquid injection method was used to detect DMF rather than headspace.

However something like DMI as a diluent might not be a bad starting point if you have no other option but to use headspace. I had no luck with it personally, but your mileage may vary.

This Agilent blurb shows how DMF holds up to other solvents in terms of FID detection limits.

https://www.agilent.com/cs/library/appl ... 9726EN.pdf
In spite of the fact that European Pharmacopoeia provides general HS-GC-FID method to determine among others DMFa & DMSO, our lab decided to develop and validate HPLC-UV methods for such residual solvents. GC-FID is fine too but liner usually degrades too fast.
Best regards,
Dmitriy A. Perlow
I don't see DMF as a problem. My short look at it today tells me I'd try to use a wax phase if possible but I can see 35 ppm in a plasticized pvc material easily using spme.

https://1drv.ms/b/s!AkH-uI0tnY5Le9xJJRT0XkjQy7E
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