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- Posts: 148
- Joined: Wed Jul 03, 2013 1:51 am
- Location: Michigan, USA
we are looking for a mild derivatization reagent for carboxylic acids for GC analysis.
Sylylation has failed for unknown reasons and we are not really set-up for doing extractive procedures (BF3/MeOH,...).
Has anyone tried the Methyl-8 reagent (N,N-Dimethylformamid-dimethylacetal)?
What are your experiences. It appears to be a very convenient way to analyze carboxylic acids as their methyl esters.
We are looking to derivatize a chiral free acid and determine the ratio of enantiomers on a chiral column.
Thanks in advance
Arne