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- Posts: 1
- Joined: Fri Oct 09, 2020 3:39 am
Hi all,
I'm setting up a method validation for GC-MS detection of volatiles in a few food matrices and am deciding on the appropriate measurements for intermediate precision acceptance criteria.
Most of the methods I've come across pool replicates run by different analysts/on different days and set a threshold level for the RSD, but I've also seen absolute difference of the mean used as well (though this was for an HPLC-MS method).
Being new to the GC, I'm not sure which measurement and what thresholds would be most appropriate (I'm assuming there is more room for variation on GC relative to HPLC-MS.) I'd appreciate any thoughts the community has!
I'm setting up a method validation for GC-MS detection of volatiles in a few food matrices and am deciding on the appropriate measurements for intermediate precision acceptance criteria.
Most of the methods I've come across pool replicates run by different analysts/on different days and set a threshold level for the RSD, but I've also seen absolute difference of the mean used as well (though this was for an HPLC-MS method).
Being new to the GC, I'm not sure which measurement and what thresholds would be most appropriate (I'm assuming there is more room for variation on GC relative to HPLC-MS.) I'd appreciate any thoughts the community has!
