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- Posts: 4
- Joined: Tue Oct 08, 2019 2:31 pm
We suspect that a contaminant in the sample matrix is co-eluting with an analyte due to a consistent discrepancy between the results of the primary and confirmation columns, where the primary column result is always higher. The contamination is not observed in standards.
Is it possible to use some technique, such as standard addition, to quantify or confirm the presence of a matrix contaminant co-eluting with an analyte in the primary column? I think this isn't possible due to the fact that we can't obtain sample without analyte or the contaminant.
An alternative would be to attempt to resolve the contaminant from the analyte, but short of selecting a new column, I'm not sure how to go about doing that.
Perhaps GC-MS could be used to distinguish the contaminant from the analyte? Can the MS distinguish spectra of two different molecules that co-elute?