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- Posts: 74
- Joined: Thu May 09, 2019 7:36 pm
I am attempting to quantify Class 3 solvents using USP 467.
In section 9 of USP 467 it says
"In that case, the procedures described in this chapter, with appropriate adjustments, are to be applied wherever possible and USP Reference Standards, where available, should be used in these procedures. Such procedures should be properly validated as described in 〈1467〉"
After trying to use mimic the procedure used for class 1 and class 2 my results haven't been looking very great.
Does anyone have experience making the appropriate adjustments?
How much can we alter/deviate from procedures described earlier in the chapter? (i.e changing column length, adding internal standard, etc.)