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- Posts: 4
- Joined: Tue Oct 23, 2012 6:53 am
I am trying to do a sample prep.
The limit of the impurity (phatalate) is 5 µg per gram API.
I want to analyze it on GC-MS in SIM.
It is actually a mass/mass determination and it is not possible for me to weigh in 500 µg of phtalate because I don't have 100 gram of API.
The solvent I will use is ACN.
What is the best way to determine the 5 ppm in gram API?
I was thinking, if 5 ppm is in 1 gram of API and I dissolve 1 gram API in 100mL, isn't it is the same as 5 mg /1000 mL = 0.5 mg /100 mL = 0.5 mg /g of API = ug /g of API?
So if I dissolve 0.5mg of phtalate in 100mL ACN, than I can analyze 5 ppm in 1 gram API right?
Sorry if my English is not correct, i am from the Netherlands.
Thank you all in advance