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- Posts: 35
- Joined: Sun Apr 08, 2018 3:17 am
I'm trying to extract analyte from tablets containing a high viscous HPMC polymer without crushing tablets and without shaking for long periods of time. Ideally I would like to simply add tablets to a flask, add a solvent, shake, dilute, and filter.
I have a couple techniques I've tried but it always seems hit or miss. I've tried adding a solution of 10% Acetic Acid in water:Methanol (90:10) and heating at 60C - 90C for 15minutes - an hour to disintegrate the tablets. Sometimes this works and the tablets fully disintegrate and sometimes they gel and I get low recovery.
Is there any osmotic techniques that I could utilized once the tablets are swelled to quickly extract analyte?
Thanks