by
Rndirk » Mon Feb 19, 2018 2:22 pm
Agree with James.
In a typical Quechers sample preparation, following the salting out step, we perform the clean up for LC and GCMSMS:
LC-MSMS
- Evaporate under nitrogen until dry
- Redissolve in starting mobile phase
- Filtrate using push-through filter vial 0.2µm
GC-MSMS
- Take 1.5mL of acetonitrile phase in dSPE tube
- Shake 2min
- Centrifuge
- Transfer part of supernatant to GC vial
As you see, no filtration for GC. But there is centrifugation and no solvent switch, so much less risk of solids remaining.