At the moment I'm trying to analyse the samples which contains hypromelose and Trimetazidine diHCl. I observed that hypromelose forms a gel that couses the detetioration of recovery of trimetazidine. I get the results at a few percent lower than the actual content of trimetazidine. It is difficult to find the conditions (H2O:CH3OH:ACN or pH or temp.) to obtain recovery ≈ 100% Do you have any experience of working on samles containing hypromelose? Do you have any idea what J con try to solve this problem?
Thank you all in advance