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- Posts: 405
- Joined: Wed Jul 18, 2012 6:45 am
- Location: Germany
My brain is on a go-slow regarding LOD/LOQ calculation. This is the scenario:
I have a linear calibration curve, measure 6 or more blanks in the same solvent and calculate the LOD from the blank values. Easy.
Now I have a sample preparation, including 10fold enrichment: I extract my samples for recovery (Let's say it is 100 % compared to the calibration in solvent) and also extract the blank matrix in the same way. I measure 6 blank extracts and apply the same formula as above. Do I then have to include the 10fold enrichtment to the LOD value I obtained from calculation or not?
Thanks in advance
Jörg