-
- Posts: 3
- Joined: Sun Mar 13, 2011 8:43 am
I have to analyze some new formulations containing Xanthan Gum. Since it clogs the column I did a clean up with SPE C18. This works fine for the assay of my drug since it is apolar, it doesn’t with the impurities. This because some of them are mid-polar. They are retained in the SPE column when xanthan gum is not present, otherwise a 10% of them pass in the aqueous fraction. This problem can be avoided with multiple loadings of the aqueous fraction in SPE column. Of course the method becomes very long.
So this is the question, how I can remove xanthan gum from the matrix of my sample? I thought 2 things: preparative GPC or CN SPE column. Any suggestion?
Thank you