Solvent for Dissolving Gums

[Dressage]

Hi,

I am attempting to analyze a compound (via HPLC) that is in a product which contains gums (iota-carrageenan, xanthan, and locust bean gum). Does anyone have suggestions of a good solvent that I could use to break down/dissolve the gums so that I could extract the active?

I've done a bit of research and ran into chloroform and hexane as possibilities.

Thanks in advance.

[unmgvar]

this strongly depends on your compound of interest characteristics and method of separation

dissolving in chlorform hexane with no other steps means going for a normal phase method in HPLC most likely. is it suitable?

you could do a liquid to liquid extraction or SPE, again depending on the nature of your compound

[Phycal]

The problem with many gums is that if you disslove them, they usually thicken up the solvent. That makes them hard to inject then. Is there a way to extract the compound from the sample, leaving the polysaccharides behind?