Stir-bar sorptive extraction (SBSE) - No thermal desorption?

Discussions about sample preparation: extraction, cleanup, derivatization, etc.

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Has anyone used SBSE (PDMS) for compounds in water without thermal desorption? Is it possible instead to drop a twister post-extraction into solvent (acetonitrile) and sonicate it to elute the analytes of interest?

(Or recommend some literature where similar methods were applied)


Sure but the idea is to do this stuff without solvents. You also "undo" all of the great preconcentrating that you did with the stir bar.

Why not just use solid-phase extraction and reconstitute in your solvent?

The stir bars can be remediated (rid of difficult to remove, heavy materials) with solvents but they don't hold up to many, many solvent extractions.

I haven't done the cost analysis but I do know that the stir bars aren't inexpensive. A single-use SPE cartridge is likely less expensive.
I remember meeting Dr. Robert Wohleb many years ago at Pittcon after he left J&W and he was just beginning work on the spinbar extractions. He was actually doing solvent desorption with them. It did reduce the solvent needed quite a bit, and was concentrating the samples because they were putting the spinbar into a 1L sample then extracting it with 1-2ml of solvent. They would just put in in an autosampler vial with solvent and after some time remove the bar, cap, and shoot. Really simple.

There was another thing they were working on that used the coating on the liner of a bottle cap instead of the stir bar. You cap the bottle, rotate it over night or however long was needed, then put the cap on a smaller vial with some solvent and shake it to extract the target analytes. I don't think I ever saw that one go into commercial use though.
The past is there to guide us into the future, not to dwell in.
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