I have a query regarding Reserve samples, in particular Blistered Tablet Reserve Samples.

We have many instances where a CMO is manufacturing bulk tablets for us and then they are sent to a packager to blister them. Currently the bulk manufacturers are holding reserve samples of the bulk tablets of an amount that is twice the amount needed for. Should we also be advising the packagers to hold twice the amount needed for testing after it has been blistered?

I am not sure right now if there is a product complaint should we instruct the manufacturer lab to test the bulk tablets or the blistered tablets.