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- Posts: 3
- Joined: Fri Feb 01, 2019 2:02 pm
I am looking for some advice on what columns we should have in our UPLC-MS.
We are running a Waters H-Class UPLC with
- Acquity UPLC Peptide BEH C18
- CSH C18
Our lab is primarily focused on peptide/PNA chemistry with some DNA work and some small molecule work. We only run gradients of water/acetonitrile + 0.1% TFA. We are looking to use formic acid on the other lines. We run time courses of reactions, purity checks of prep HPLC fractions, reaction monitoring, identification of products by MS.
If we wanted to invest in a new column or two what would add to our capabilities or improve what we currently have?