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- Posts: 4
- Joined: Wed Jan 30, 2019 8:00 am
Cerebrotendinous xanthomatosis is a genetic disease that requires permanent use of medication chenodeoxycholic acid to avoid critical effects such as mental retardation, cataracts, mobility and others. My wife unfortunately suffers from this disease. Unfortunately it is prohibitively expensive (>$20k/month) so in order for her not to suffer and die I must purchase raw API, encapsulate and give to her. Although I try my best to verify that the suppliers I purchase from are trustworthy I still cannot trust them, so I need to test the API.
There's one guy that provides this service, but unfortunately in the past he has been caught lying to customers (saying he tested something he actually didn't) and his trust is shattered.
He sent me chromatogram of chenodeoxycholic acid standard he said purchased from sigma and the sample I sent him. I found it odd because the baseline isn't straight, there were multiple peaks eluted, some even very close to the retention time of the drug. Still he said it's 98%+ pure. When I asked him about it he said "chenodeoxycholic acid has extremely weak signal of 5" which I found very odd because there are several CDCA chromatograms on the internet with normal characteristics (straight baseline, only one peak except for impurities). To make it worst, I don't believe this is a 98%+ pure sample (perhaps 95%+) because I didn't store it 100% properly and it's months old already.
I need help verifying if he actually did the work and if he did it was a competent one for this matter is important.
His test on standard from sigma: https://www.docdroid.net/9suhIXC/chenod ... 19-002.pdf
His test on my sample: https://www.docdroid.net/QMqdUB1/394-39 ... 19-002.pdf
Thank you very much!