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Viscosity and priming

http://www.chromforum.org/viewtopic.php?f=1&t=92194

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Viscosity and priming

Posted: Wed Jan 09, 2019 3:05 pm
by BL__
(debate at work) Why are lower viscosity solvents preferred when priming the systems (after buffer was washed out). Are they somehow better at removing air bubbles?

I'm guessing the answer is simple, I just don't see it.

Re: Viscosity and priming

Posted: Wed Jan 09, 2019 5:22 pm
by EmpowersBane
Possibly because the higher viscosity liquids stick to and clog up the check valves on HPLCs and UPLCs quicker than lower viscosity ones?
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