by
DRVKS » Mon Aug 06, 2018 11:37 am
HPLC chemist wrote:
As I recall HPMC is a polymer and will have the same peaks, thus the RT is the same. The grade of HPMC is dependant on the quantitation of the peaks or the main peak (like PCB's). Rather than HPLC, you may be better off measuring the viscosity over time (like corn starch).
Hi Thanks for your response but in a compressed tablet how you can quantify by measuring viscosity as it also contain other excipients.
the concern is separation and quantification of two different grades of HPMC (having difference in molecular weight of around 1000000) from a Tablet.
I hope my concern is clear now.
Regards