We did some attempts at forced degradation in our validation studies, but most times we were unable to cause any measurable degradation under the "usual" conditions. We tried more acidic, more basic, longer exposures, etc., as well. Our consumer products were pH controlled and monitored over their 3-year ambient and elevated temperature studies, and our QA department felt that we would be able to detect degradation.
For example, we had a sunscreen active that was found not stable with the chosen preservative, so that preservative was changed.
Another active was confirmed reacting with an excipient as product development had been warned, so that project was ditched. Early in my career I confirmed similar in another product, product developer tried to blast me with "his PhD" but it turned out that I was correct.
Not a drug issue, but an enzyme in a laundry detergent was shown to be unstable due to degradation caused by a different enzyme.
Unfortunately, the company I worked for seemed to enjoy killing the messenger too often.....