Cleaning Validation for Dexmedetomidine

Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.

2 posts Page 1 of 1
Hi,


I have developed a method for cleaning validation of dexmedetomidine. Concentration is very low (0.0000001 mg / ml=%100 standard). I hava obtained a peak with HPLC and LC MS MS. However I have not provided linearity in both methods. Area of %120 standard less than % 100 standard. I have tried methods too much. Is the range not appropriate in the methods.

Thank you
Good afternoon,

This may help a bit:

https://www.europeanpharmaceuticalrevie ... n-samples/
MattM
2 posts Page 1 of 1

Who is online

In total there are 2 users online :: 1 registered, 0 hidden and 1 guest (based on users active over the past 5 minutes)
Most users ever online was 1117 on Mon Jan 31, 2022 2:50 pm

Users browsing this forum: Google [Bot] and 1 guest

Latest Blog Posts from Separation Science

Separation Science offers free learning from the experts covering methods, applications, webinars, eSeminars, videos, tutorials for users of liquid chromatography, gas chromatography, mass spectrometry, sample preparation and related analytical techniques.

Subscribe to our eNewsletter with daily, weekly or monthly updates: Food & Beverage, Environmental, (Bio)Pharmaceutical, Bioclinical, Liquid Chromatography, Gas Chromatography and Mass Spectrometry.

Liquid Chromatography

Gas Chromatography

Mass Spectrometry