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- Posts: 104
- Joined: Tue Aug 04, 2015 9:57 pm
A lab with a long standing tradition of utilizing external standards (in water) for analysis of sugars (glucose, fructose, sucrose, maltose) in various fruit juice concentrates - a uniform method has been developed for this that does display adequate resolution for these compounds in the external standards. Detector is RI
After being questioned on a confusing result it has been discovered that (ah ha) the various concentrates have additional peaks that often do not have appropriate resolution from the peaks of interest - < 1.5
Leaving aside the possibility of actulal co-eluters for the moment, I actually see our only options as
1 - trying to develop a separate method for each product (literally dozens) and hoping that adequate separation from all interfering peaks can be achieved for all analytes for all matrices in a reasonable time frame.
or
2 - Running standard addition on every sample
Am I viewing this correctly? Are there other options beyond the two listed above? Or is there a valid argument to continue to run external standards in water for this multiple matrix situation as I don't see a scenario where that could be called a good practice going forward.