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Phosphoric acid reactivity with IP reagent
Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.
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Does anyone know if phosphoric acid can react with the ion pairing reagent Sodium 1-decanesulfonate? I am seeing several late-eluting system peaks that get bigger and more plentiful from one day to the next. 100% Milli-Q water injection, C18 column, Water/ACN are other components of mobile phase gradient. Any alternate ideas of what is happening or ways to prevent this would be appreciated. Thanks!
- tom jupille
- Site Admin
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- Location: Alamo, CA / USA
My first guess would be microbial metabolic products.
-- Tom Jupille
LC Resources / Separation Science Associates
tjupille@lcresources.com
+ 1 (925) 297-5374
LC Resources / Separation Science Associates
tjupille@lcresources.com
+ 1 (925) 297-5374
2 posts
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