Green Solvents?

Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.

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Anyone know of examples of 2-methyltetrahydrofuran being used for GPC/HPLC in place of THF?

Any other substitutions for organic solvents such as chloroform and DMF that have been used to make GPC/HPLC more environmentally friendly?
Anyone know of examples of 2-methyltetrahydrofuran being used for GPC/HPLC in place of THF?
I'm not aware of any.

Any other substitutions for organic solvents such as chloroform and DMF that have been used to make GPC/HPLC more environmentally friendly?
THF, DMF, chloroform, etc. can all be "environmentally friendly" if they are recovered for re-use (e.g., by distillation) -- assuming, of course, that one ignores the generation of the required energy. I rather suspect that the consumption of solvents for analytical-scale chromatography is a small fraction of that used in process-scale applications.

For GPC, the choice of solvent is based on four priorities (in this order):
- does the analyte dissolve in it
- can the detector see through it
- is it hazardous
- is it environmentally friendly
-- Tom Jupille
LC Resources / Separation Science Associates
tjupille@lcresources.com
+ 1 (925) 297-5374
2 posts Page 1 of 1

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