fexofenadine [January 1, 2004]

By mitali on Thursday, January 1, 2004 - 06:29 am:

i want to know the method for seperation of fexofenadine HCLtablet and its impurities namely 4 impurities metafexofenadine,ketofexofenadime,
methyl ester of fexo and methyl ester of keto fexo HCL

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By Uwe Neue on Thursday, January 1, 2004 - 07:43 pm:

Mitali:
I have not done this assay, but we have worked with fexofenadine. Its retention varies nicely with pH, which allows you to optimize the method by playing with the pH. We worked with XTerra RP18 (also with XTerra MS C18). In 30% acetonitrile, the retention factor changed from 4 at very acidic pH to 2 around neutral pH to values abov 4 at pH 10 again.

Hope this gives you a good start.

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By mitali on Monday, January 5, 2004 - 06:08 am:

dear uwe,
thank u for ur suggestion.i will get back to u
after i research a more on it.
hope to keep in touch