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Hi all,
Can anybody tell me under what signal to noise ratio (S/N) quantitation is not reliable anymore? How can we relate the S/N to the precision (accuracy) of quantitation? What is the document or literature that gives specifications on this issue?
Thank you very much for your time and attention.
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By Anonymous on Sunday, January 11, 2004 - 09:36 pm:
Generelly, limit of detection (LOD) is set to 3:1 S/N and limit of quatitation (LOQ) to 10:1 S/N.
You should also test the injection precision at LOQ by preparing a sample that gives the S/N 10:1 ratio. This is usually max RSD% 10 or 5.
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By Fahim Gouveia on Monday, January 12, 2004 - 07:45 am:
Thanks for the reply. What is the source (eg.,document or literature) that specifies these values? What is the meaning of RSD% (I´m sorry, but never heard about it)?
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By Anonymous on Monday, January 12, 2004 - 08:23 am:
What is the source (eg.,document or literature) that specifies these values?
Try checking the USP.
What is the meaning of RSD%
RSD=relative standard deviation
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By syx_gf on Thursday, May 20, 2004 - 05:31 pm:
%RSD = Coefficient of variation (RSD x 100)
RSD = SD/mean
%RSD = 100 x SD/mean
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By Chemist on Tuesday, June 1, 2004 - 04:17 am:
Fahim, are you sure you working with LC?
Never heard of %RSD?
How do you now precision of instrument injections, sample reproducibility, etc...???