Hi,

I'm at a very small pharma company with a start-up budget. We are in the unfortunate position of needing to run flash chromatography on 900 grams of material. We have a small combiflash that we started our work on, but it's not up to the task this time; so, I need to source something larger. I looked at the biotage 75 and it appears I can get that relatively cheap on ebay. However, I would still need to source a detector, and we want a gradient so I need pumps as well. We are comfortable mixing and matching pieces together.

Anyone have any suggestions/recommendations/tips? Are there other brands out there? Am I thinking too small with the biotage 75? Any inexpensive pump manufacturers? Do you know of any sources for these systems refurbished or used? Also, would it be easier to skip the gradient and just switch pre-mixed mobile phase bottles?

Thanks in advance!