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For instance, a famous zwitterionic column on extended usage developed a few mm deep void. It is a polymer coated silica; in this case the retention times were relatively stable but most the underlying silica dissolved with time.
I regularly see new HILIC phases in chromatography journals but most of them are silent about their stability with few exceptions for reliable names. What is your experience for HILIC stability? It might be appropriate to discuss generic stationary phase chemistry rather than company names to maintain neutrality.
Thanks.