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- Posts: 14
- Joined: Thu Oct 12, 2006 3:01 pm
- Location: Germany
is there a downside to use a different organic solvent in the diluent (methanol) than in the mobile phase (acetonitrile). The aqueous part is identical (water with phosphoric acid)
The peak shape is perfect, the base line as well.
Of course, at the front you have a significant solvent peak, but which does not interfere with the active peak to be integrated.
Is there any faster column deterioration etc. to be expected?
Thank you very much!
Regards,
FJ