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- Posts: 1
- Joined: Mon Jan 09, 2012 11:19 pm
I like to know if anyone has experience analyzing a drug in castor oil by HPLC. I like to avoid using Normal Phase HPLC or GC. The drug has very poor aqueous solubility, excellent solubility in Acetonitrile, that's all I know so far. I need to find a way to dissolve the drug in castor oil and some other solvent, then inject it onto HPLC to get solubiltiy data for now, eventually I will need to have the method validated. I'm thinking about trying IPA or Methanol in Castor oil, I don't know how it will go, also does anyone know if I can make a final dilution in acetonitrile, is IPA/ACN or Methanol/ACN miscible?
What about impurities in Castor Oil, it is NF grade, what else do I need to look for or keep in mind when developping the method?
Thanks so much!