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- Posts: 148
- Joined: Wed Jul 03, 2013 1:51 am
- Location: Michigan, USA
we are running an SFC system with good success in our lab. I am suspecting that in reality we are doing subcritical chromatography or that our system becomes subcritical (liquid) during gradients.
Our standard method is at 30°C, which is below the Tc of pure CO2.
From a publication (J. Chem. Eng. Data 2000, 45, 932-935) it appears that the ciritcal temperature rises as alcohols are added. For 15% methanol it is approximately 50°C.
Am I getting something wrong?
What are the effects of crossing the Tc during a gradient method at 40°C and 5-40% MeOH?