Accetable retention time drift for system suitability?

[chemist23]

What are acceptable limits for retention drift in LC for system suitability requirements?

I seen some such as 2%,5% and even 10% difference. What is the most common?

[tom jupille]

No single answer to that. Among other things, it depends on the resolution of your analytes from interferences. As a broad generalization, it should be small enough to prevent mis-identification of peaks.

[pwm]

For our OQPQ it is NMT 0.3%RSD on six replicates of caffiene.