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M537 PFC analysis challenges
Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.
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Hi all, I am working on setting up a new EPA Method 537 at our lab for the analysis of perfluorinated compounds. We are having trouble with low recoveries of the lighter/early eluting compounds (i.e. PFBS, PFHxA). Everything recovers well when run as a pure standard, but the problem arises when doing the extraction with actual water samples. Anyone have thoughts on possible causes of the losses? Thanks!
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The following step is the most likely to cause problems with lighter, more volatile compounds: The extract is concentrated to dryness with nitrogen in a heated water bath,
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