Normal Phase seals for only heptane and EtOH/iPOH?

[Arne]

Hi All,

we do do a lot of normal phase and we have our dedicated systems equipped with normal phase seals. However, I suspect that those are necessary for usage of DCM, MTBE and such. We are looking to deliver a method to a customer who is usually only doing RPLC and the method "only" uses heptane and an alcohol that is also an RPLC solvent - most likely EtOH or iPOH. Are the seals necessary for that combination? I doubt that it is super agressive, since one can even use coated silica columns. Thank you so much in advance for input!

Best
Arne

[lmh]

Probably depends on the exact system. I have a horrible feeling that ethyl acetate and hexane killed Shimadzu Nexera reverse phase seals unpleasantly quickly.