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- Posts: 9
- Joined: Fri Sep 08, 2017 4:29 pm
I posted a while back about having precision issues with my sample (20-40% difference in peak areas). This is for my Agilent 1200 series HPLC with a 6130 MSD. Here is the link to the other post: viewtopic.php?f=3&t=49114
I just had my PM with Agilent where rotors and seals, etc. were replaced in the autosampler which I thought was the cause, but I still see the issues.
The last thing I can think of before getting Agilent repair to tear apart the autosampler is the column. I see slight tailing on my chromatograms and I think this is due to it being an old column. Can LC columns cause precision issues? Do you have any other suggestions as to what I could look at? Are there Agilent MSD standards that I could run to ensure that it is the machine and not my sample causing the issue?