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Seen lab results that when diluted by a factor of 10, it raises the LOQ by a factor of 10 making it an unusable number. Isn't the LOQ a measure of instrument performance and not take into account dilution?
Discussions about GC-MS, LC-MS, LC-FTIR, and other "coupled" analytical techniques.
HPLC chemist wrote:
The original is probably not a true LOQ which is why I prefer the statistical calculation of the LOQ based on the sum of the residuals (standard deviation). Factors that influence the LOQ are injection volume, detector, flow, interferences...
JWF239 wrote:HPLC chemist wrote:
The original is probably not a true LOQ which is why I prefer the statistical calculation of the LOQ based on the sum of the residuals (standard deviation). Factors that influence the LOQ are injection volume, detector, flow, interferences...
Right, so if I have my LOQ calculated from LOQ = Blank response + 10*STD Dev
Of a set of blank samples then that value should not change when I dilute a sample, right?
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