Splitless Parameters

[Chemist83]

I forgot to mention that the method contains parameters for CTC/PAL but was validated using agilent G1888 Headspace Sampler (transfer line).
Does the G1888 gives more accurate results?

[AaronAIT]

If the method was validated on a G1888 then it would not have had the initial parameters you listed such as injection volume (as it is a fixed size loop on G1888) or injection speed. Also it would have most likely have the split vent open if a transfer line was used.

As for whether it's a more accurate instrument, that would depend a lot on the method parameters. However in my experience they are quite robust instruments, and with well optimised methods they have rarely let me down.

[MSCHemist]

My main gripe with loop and valve headspace samplers is caryover. I have problems with caryover of alcohols, carboxylic acids and aldehydes even with the deactived silicosteel line (5% or so). Another variable listed is the septa purge loss but I haven't found that to be a big issue.

[Chemist83]

The method contains an option for both CTC/PAL and agilent G1888-transfer line, but the validation of the method was only done with G1888.