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- Posts: 104
- Joined: Sun Sep 13, 2015 7:54 am
I seem to be getting a random pressure spike in random injections - to me I think it looks like it could be air. I don't get this if I am just running mobile phase, it only happens if I do an injection and it's not every injection.
Furthermore, just last week or so the instrument ran perfectly fine, I just noticed it when I ran a sequence this past Thursday and again yesterday. I don't see any air bubbles in the syringe when the system injects, so...
I am just here to get some more ideas as to where I might look. Do I need to do a more thorough cleaning and purging of the syringe and loop? Here's a chromatogram of the pressure spike and what I am getting on my detector response when it happens. I was fortunate enough that it didn't overlap with any of my actives, or appear close enough to influence the results.