Not "
UPLC". Wrong term as that is a trademark belonging to Waters Corp. You mean UHPLC or HPLC (UHPLC is HPLC). If you call it HPLC, you will always be using the correct terminology. UHPLC was just created as a marketing name. Here is a link on the web which will explain it to you (
https://hplctips.blogspot.com/2015/08/t ... lc-or.html )
Most of the big brands are good, but you should put together some test samples (3-5 know samples with methods that you are familiar with, not unknowns) and arrange to have demos of the different systems at the vendors application lab location to try them out. Be sure and study the software (In some ways the selection of software is as or even more important than the hardware) and certainly bring 1 or 2 other people with you who have many years of professional experience using and troubleshooting HPLC systems (any brands).
Asking people on a group like this for advice on which system you should buy is not the best approach. These people are not you. They do not run your samples. They do not have the same training as you or have the same needs as you. Groups can offer advice regarding their personal experience with service contracts or long term problems, but not on what is best for you.