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- Posts: 366
- Joined: Wed Feb 02, 2005 9:34 pm
In our lab we are now trying to move from 4.6 and 3 mm ID columns to the use of 2 mm ID columns (in order to minimize solvent use and waste generation). Now, of course, the flow rate that one must use is lower with these narrower ID columns. A typical flow rate for a 0.2 mm ID column would be something like 0.2 or 0.25 mL/min.
So I wanted to get some opinions on this question: With modern HPLC systems, how low can you go in flow rate, and still be confident that the flow rate will be delivered reliably?
Thanks in advance for any feedback!