Persistent Leak with certain Mobile Phase

[daniel.rodger]

Hi,

We currently have an issue with persistent leaks for a few methods that we run. The methods all have the same mobile phase (Water, methanol, octane sulfonic sodium salt, phosphoric acid, and diethylamine) and we seem to get leaks from any line joins. The leaks are not big, it wouldn't be enough to set the sensor off but over time there is clearly a build up of eluent residue.

We've tried different kits, Agilent 1100's and 1200's, and get it which ever kit it is. Putting a different method on a previously kit doesn't result in leaks as well.

What are peoples thoughts/possible solutions?

It could just be that joints aren't being made well enough but I'd like some second opinions.

Thanks

[Peter Apps]

Welcome to the forum.

It's possible that the joints leak all the time, but it is only this particular phase that gives obviously visible salt deposits.

Peter

[James_Ball]

Welcome to the forum.

It's possible that the joints leak all the time, but it is only this particular phase that gives obviously visible salt deposits.

Peter

This is what I was thinking. We see tiny amounts of salt deposits when using similar mobile phases over time, but never when using pure water or solvent without the additives.

[dblux_]

How high is the pressure during your runs, chromatographic runs of course ?

[daniel.rodger]

Cheers for the replies, yeah that agrees with what I was thinking.

Typical pressure is ~250bar so they should be very comfortable at that

[dap]

Is degasser a source of leaks? What is the source any way?