Hey guys, I have a question about the method of omeprazol in USP, nowadays I am having problems with this product, as my demand is great, I usually have efficiency problems very quickly, have any of you already encountered this problem? How did they solve it?

I use the method of USP with gradient and buffer in glycine, my collumn is a Xterra MS C8 150x46mm 5mc.

I have saw that the fritz of my collumn clog easily and I do not know the cause, both the mobile phase and the samples are filtered on a 0.22mc filter.

Thanks to the help.

More one time, sorry my english I,m brazilian.