agilent 1260 or ultimate 3000

[yara]

our lab is going to purchase a new HPLC-uv device,we are comparing between two devices agilent 1260 and thermo dionex ultimate 3000,which is better (pros and cons )of each device?? thanks in advance

[PeakAnalyticalSys]

please provide your contact details we have both Agilent 1260 or Ultimate 3000 system in stock.
we can find a better solution for your requirement.

Regards
Afzal Husain (+919920217337)

[Alfred88]

I strongly recommend to go with the Dionex Ultimate 3000.
The software for the Agilent system will require significant capital, up to 50K USD for one system, to meet Part 11 requirements. Software for Dionex is approx. 10K USD.

In addition, the design of the Agilent autosampler will generate very high carryover (1.5 - 2%). The poorly designed unit can introduce foreign materials (e.g. dirt from vials' bottom) into the injection port, because the vials are removed from their locations, and put right on the injection port prior to needle penetration and liquid aspiration.

[kubowicz.tomasz]

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In addition, the design of the Agilent autosampler will generate very high carryover (1.5 - 2%). The poorly designed unit can introduce foreign materials (e.g. dirt from vials' bottom) into the injection port, because the vials are removed from their locations, and put right on the injection port prior to needle penetration and liquid aspiration.

If you have Agilent well plate sampler , vial are not removed! Sampler arm is moving from vial to vial.

Regards

Tomasz Kubowicz

[andy_s]

We have an use both in our group, for different jobs. I have far more experience+training with Agilent kit, and I've only started getting into the Dionex recently. I am a synthetic chemist who has ended up laregly in charge of the LC facilities in a large, varied, academic group. We use our machines on many projects, so flexibility is key - if you want somethign to do the same thing for 5 years, then you're looking for something different to me.

Some (probably biased, hopefully useful) thoughts:

To my mind the Agilent (+software) are far more suited to a large number of users fiddling with them to work on many different projects/methods - they are more intuitive to use and more robust. I can let students fiddle with little training. Our Agilent 1260 autosampler leaves the vials where they are, and has a good needle wash mechanism - we have had no noticable problems with carry-over. I find Agilent kit better at talking to different MS systems' software. I like Agilent.

In contrast, we have found the Dionex to be better technically (more precise) and arguably easier to work with to do complex stuff (e.g. complex derivitisation protocols, hooking up to self-bult onlline analysis systems). The after-sale support from Dionex was a night/day contrast to Agilent (which was almost non-existent) - they have been wonderful. I like Dionex people. Talking to MS software is a mixed bag - e.g. Dionex communication with Masslynx is a bodge; with Hystart, however, it is good - arguably better than Agilent.

I would buy both machines again. One deciding factor for us is often what we have already, and can it all work on the same software + data systems. Worth thinking about....